Do not give your Holland Lop a bath. They are very clean creatures and bathing them can harm them as they will panic in water and may fracture a limb or back. Wet fur can also lead to hypothermia and respiratory disease. Hot water or a hair dryer can scald their skin. If something is very dirty, you can spot clean them with a rag and warm water and maybe dry the fur with a blow drier on a cold setting, but be careful, the noise could scare them.

 

When it comes to grooming, your rabbit(s) need to be brushed weekly. They do self-groom, but this helps them so they don't ingest too much hair and cause blockages. It is in their best interest if you remove most of the hair. They may need extra brushing while they are molting, which typically occurs for a few weeks once a year.

 

Their nails also need to be checked and trimmed regularly. Have your veterinary teach you and if it really scares you, take them to the vet for them to do it safely.

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Like all rabbits, the Holland Lop will need their teeth checked regularly. Overgrown teeth can be very painful and cause significant problems, like infections. A correct diet should be enough to keep the teeth worn down, though a trip to the vet can trim down their teeth as well.

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Wire-bottom cages should be avoided. These are bad for their feet and can cause sores. 

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Younger rabbits are particularly prone to enteritis, gut stasis, and bloat. All of these issues can possibly be deadly. Because of their lop ears, they are also prone to ear infections. Keep their ears clean and well-groomed. Parasites are possible, especially mites. They tend to get these from other rabbits or outside areas. Parasites are easily treatable with a spot-treatment or injection. They are not typically deadly or serious, but they can be extremely annoying for the rabbit.

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When in doubt, always consult with your rabbits veterinarian.  Make sure you locate one that has experience with rabbits.